KCNN2

Across TCGA patient cohorts, KCNN2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNN2-associated genes across cancer lineages are PRAS40_pT246, 53BP1, and eIF4E. Each is linked with KCNN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNN2-to-partner and partner-to-KCNN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by KCNN2-low versus KCNN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNN2→partner) and Y-score (partner→KCNN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.164	+2.222	.007	.010	3	3
UCEC	53BP1 →	+0.249	+2.584	.043	.010	3	3
UCEC	eIF4E →	+0.149	+1.887	.049	.029	3	2
UCEC	Akt_pT308 →	+0.510	+2.115	.024	.016	3	2
UCEC	Tuberin_pT1462 →	+0.190	+1.594	.022	.021	3	2
UCEC	beta-Catenin →	+0.361	+2.459	.048	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PRAS40_pT246 by KCNN2 expression — UCEC

Explore this box plot interactively →