KCNN2

Across TCGA pan-cancer cohorts, KCNN2 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated KCNN2 data layer compared with 10 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KCNN2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KCNN2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCEC show a favorable association.

KIRC, UCEC, and MESO are the cancer types where KCNN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.729	0.569	.001	84	view →
UCEC	DFS	Median	II,III,IV	0.904	0.744	<.001	70	view →
MESO	OS	Quartile	All	0.283	0.623	<.001	46	view →
LGG	DFS	Median	All	0.802	0.672	<.001	44	view →
SCLC	DFS	Tertile	IV	0.174	0.776	.029	12	view →
LUSC	DFS	Quartile	II,III,IV	0.592	0.761	.013	12	view →
SKCM	DFS	Median	III,IV	0.582	0.398	.009	9	view →
COAD	DFS	Median	IV	0.347	0.635	.015	8	view →
BRCA	OS	Tertile	II,III,IV	0.468	0.660	.029	7	view →
HNSC	DFS	Quartile	IV	0.669	0.485	.020	7	view →
STAD	OS	Tertile	All	0.451	0.711	.025	6	view →
CHOL	OS	Median	III,IV	0.275	0.886	.045	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

KCNN2–KIRC (OS)

Open the KIRC breakdown →