KCNMA1

Across TCGA patient cohorts, KCNMA1 mutation is significantly associated with the RNA expression of many other genes, with 7,666 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNMA1-associated genes across cancer lineages are MED18, ZFYVE19, and ECI1. Each is linked with KCNMA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both KCNMA1-to-partner and partner-to-KCNMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED18 grouped by KCNMA1-low versus KCNMA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNMA1→partner) and Y-score (partner→KCNMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MED18 →	+0.399	+1.768	<.001	<.001	3	5
COAD	ZFYVE19 →	+0.472	+3.247	<.001	<.001	3	5
STAD	ECI1 →	+0.522	+2.725	<.001	.002	3	5
UCEC	PGAM1 →	+0.615	+2.436	<.001	<.001	3	5
UCEC	TYMSOS →	+0.767	+2.061	<.001	<.001	3	5
STAD	RPARP-AS1 →	+0.629	+2.662	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,666 associations by consensus.

MED18 by KCNMA1 expression — UCEC

Explore this box plot interactively →