KCNK7

Across TCGA patient cohorts, KCNK7 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. COAD shows the largest number of these associations.

The most reproducible KCNK7-associated genes across cancer lineages are G6PD, Mre11, and 14-3-3_epsilon. Each is linked with KCNK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK7-to-partner and partner-to-KCNK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G6PD grouped by KCNK7-low versus KCNK7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK7→partner) and Y-score (partner→KCNK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	G6PD →	+0.205	+2.815	.048	.036	3	1
COAD	Mre11 →	+0.183	+2.820	.004	.035	3	1
COAD	14-3-3_epsilon →	+0.169	+2.849	.016	.034	3	1
COAD	Smad4 →	+0.182	+2.815	.012	.036	3	1
COAD	Stathmin →	+0.243	+2.815	.003	.036	3	1
COAD	YAP →	+0.275	+2.815	.049	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

G6PD by KCNK7 expression — COAD

Explore this box plot interactively →