KCNK7

Across TCGA pan-cancer cohorts, KCNK7 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KCNK7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KCNK7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCNK7 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

KIRC, THCA, and BRCA are the cancer types where KCNK7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNK7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.490	<.001	11	view →
THCA	All	All	+0.259	<.001	8	view →
BRCA	All	III,IV	−0.429	<.001	6	view →
KICH	All	All	−0.342	<.001	6	view →
LIHC	All	All	+0.213	<.001	6	view →
LUAD	Female	All	−0.380	<.001	5	view →
LUSC	All	All	+0.720	<.001	4	view →
HNSC	All	II,III,IV	−0.684	.042	2	view →
CHOL	All	All	+0.654	<.001	2	view →
KIRP	All	IV	+0.355	.006	2	view →
PRAD	All	All	−0.240	<.001	2	view →
COAD	All	III,IV	−0.229	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KCNK7–KIRC

Open the KIRC breakdown →