Across TCGA pan-cancer cohorts, KCNK4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KCNK4 data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KCNK4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KCNK4 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

UCEC, KIRP, and BRCA are the cancer types where KCNK4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
KIRP	OS	Median	All	0.192	0.705	.015	4	view →
BRCA	DFS	Median	II,III,IV	0.661	0.889	.046	4	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →
SKCM	DFS	Median	All	0.570	0.194	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: KCNK4 tumor-vs-normal RNA expression · all KCNK4 data types