Across TCGA pan-cancer cohorts, KCNK4 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of KCNK4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KCNK4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCNK4 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.

HNSC, BLCA, and KIRP are the cancer types where KCNK4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNK4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.041	.018	3	view →
BLCA	All	IV	+0.040	.049	1	view →
KIRP	Male	All	−0.019	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: KCNK4 RNA expression & survival · all KCNK4 data types