Across TCGA cell cohorts, KCNK4 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KCNK4-associated genes across cancer lineages are LYPD2, QRFPR, and OR5K4. Each is linked with KCNK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK4-to-partner and partner-to-KCNK4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK4→partner) and Y-score (partner→KCNK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LYPD2 →	+0.128	+4.152	<.001	.009	3	2
LARGE_INTESTINE	QRFPR →	+1.212	+3.854	<.001	.006	3	2
STOMACH	OR5K4 →	+0.143	+5.285	<.001	.003	3	1
BLOOD_Leukemia	GPR101 →	+0.167	+4.551	<.001	.004	3	1
BLOOD_Leukemia	NKX2-6 →	+0.507	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	NPAP1 →	+0.075	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

KCNK4 survival (RNA) · tumor vs normal (RNA) · all KCNK4 data types