KCNK16

Across TCGA pan-cancer cohorts, KCNK16 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KCNK16 data layer compared with 17 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KCNK16 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KCNK16 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, COAD, and CCRCC are the cancer types where KCNK16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.484	.038	18	view →
COAD	DFS	Median	II,III,IV	0.877	1.000	.016	12	view →
CCRCC	OS	Median	II,III,IV	0.228	0.979	.003	12	view →
PDAC	DFS	Quartile	All	0.679	0.807	.002	9	view →
LSCC	OS	Tertile	All	1.000	0.913	.013	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KCNK16–HNSC (OS)

Open the HNSC breakdown →