KCNK1

Across TCGA pan-cancer cohorts, KCNK1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KCNK1 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KCNK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KCNK1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where KCNK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.356	0.845	<.001	36	view →
PDAC	DFS	Tertile	III,IV	0.284	0.988	.006	15	view →
LUAD	DFS	Quartile	All	0.788	1.000	.012	8	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.403	.018	4	view →
HNSC	DFS	Tertile	All	0.883	0.634	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KCNK1–LSCC (DFS)

Open the LSCC breakdown →