KCNJ9

Across TCGA cell cohorts, KCNJ9 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KCNJ9-associated genes across cancer lineages are OR12D3, TOPAZ1, and ARGFX. Each is linked with KCNJ9 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ9-to-partner and partner-to-KCNJ9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D3 grouped by KCNJ9-low versus KCNJ9-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ9→partner) and Y-score (partner→KCNJ9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR12D3 →	+0.056	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	TOPAZ1 →	+0.013	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	ARGFX →	+0.032	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.027	+4.887	<.001	.009	3	1
LARGE_INTESTINE	UGT2B4 →	+0.844	+3.556	.001	.007	3	1
LARGE_INTESTINE	TSPY8 →	+0.076	+3.297	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR12D3 by KCNJ9 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →