KCNJ6-AS1

Across TCGA pan-cancer cohorts, KCNJ6-AS1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of KCNJ6-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where KCNJ6-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types KCNJ6-AS1 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

BRCA, HNSC, and LUSC are the cancer types where KCNJ6-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNJ6-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	−0.166	<.001	6	view →
HNSC	Female	III,IV	+0.216	.039	3	view →
LUSC	Female	III,IV	+0.260	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

KCNJ6-AS1–BRCA

Open the BRCA breakdown →