KCNJ3

Across TCGA patient cohorts, KCNJ3 mutation is significantly associated with the RNA expression of many other genes, with 5,726 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ3-associated genes across cancer lineages are EZH2, KNL1, and CHEK1. Each is linked with KCNJ3 in more than 4 cancer types. Because this analysis shows association rather than direction, both KCNJ3-to-partner and partner-to-KCNJ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EZH2 grouped by KCNJ3-low versus KCNJ3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ3→partner) and Y-score (partner→KCNJ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EZH2 →	+0.399	+2.695	.001	<.001	3	5
UCEC	KNL1 →	+0.606	+3.157	<.001	<.001	3	5
UCEC	CHEK1 →	+0.612	+1.642	<.001	<.001	3	5
LUSC	ASPM →	+0.654	+3.629	<.001	.001	3	5
UCEC	ERCC6L →	+0.550	+3.332	<.001	<.001	3	5
UCEC	RACGAP1 →	+0.557	+2.223	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,726 associations by consensus.

EZH2 by KCNJ3 expression — UCEC

Explore this box plot interactively →