KCNJ3

Across TCGA patient cohorts, KCNJ3 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ3-associated genes across cancer lineages are A-Raf_pS299, Acetyl-a-Tubulin-Lys40, and MIG-6. Each is linked with KCNJ3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNJ3-to-partner and partner-to-KCNJ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by KCNJ3-low versus KCNJ3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ3→partner) and Y-score (partner→KCNJ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	A-Raf_pS299 →	-0.114	-2.662	.033	<.001	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.600	+2.700	.003	.005	3	2
SKCM	MIG-6 →	+0.154	+2.321	.009	.032	3	2
UCEC	eIF4E →	+0.171	+1.678	.003	<.001	3	2
UCEC	Gab2 →	+0.234	+1.415	.018	.040	3	2
UCEC	Ku80 →	+0.201	+1.013	.002	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

A-Raf_pS299 by KCNJ3 expression — SKCM

Explore this box plot interactively →