KCNJ2

Across TCGA patient cohorts, KCNJ2 mutation is significantly associated with the RNA expression of many other genes, with 2,276 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ2-associated genes across cancer lineages are DYNLT3P2, HSPE1P14, and TPI1. Each is linked with KCNJ2 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNJ2-to-partner and partner-to-KCNJ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYNLT3P2 grouped by KCNJ2-low versus KCNJ2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ2→partner) and Y-score (partner→KCNJ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DYNLT3P2 →	+0.272	+1.643	<.001	.001	3	4
LIHC	HSPE1P14 →	+0.081	+3.268	<.001	.007	3	3
SKCM	TPI1 →	+0.552	+3.623	<.001	.001	3	3
SKCM	GOT1 →	+0.553	+2.254	<.001	.006	3	3
SKCM	MED9 →	+0.466	+2.228	<.001	.006	3	3
SKCM	ANKRD9 →	+1.029	+3.372	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,276 associations by consensus.

DYNLT3P2 by KCNJ2 expression — UCEC

Explore this box plot interactively →