KCNJ18

Across TCGA pan-cancer cohorts, KCNJ18 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated KCNJ18 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KCNJ18 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KCNJ18 expression acts as an unfavorable survival marker, although some lineages such as HNSC and THCA show a favorable association.

HNSC, LUAD, and ACC are the cancer types where KCNJ18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.727	0.587	<.001	137	view →
LUAD	DFS	Tertile	All	0.577	0.706	<.001	82	view →
ACC	DFS	Tertile	III,IV	0.029	0.473	<.001	48	view →
LUSC	OS	Median	All	0.736	0.892	.001	44	view →
UCEC	DFS	Tertile	All	0.468	0.708	.001	34	view →
OV	OS	Quartile	All	0.740	0.866	<.001	26	view →
KICH	OS	Tertile	II,III,IV	0.760	0.928	.018	21	view →
PAAD	OS	Tertile	II,III,IV	0.239	0.438	.030	18	view →
SCLC	OS	Tertile	IV	0.137	0.556	.025	18	view →
THCA	DFS	Tertile	All	0.978	0.923	.011	18	view →
THYM	OS	Median	All	0.581	0.956	.003	17	view →
KIRP	OS	Tertile	All	0.512	0.739	.015	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

KCNJ18–HNSC (OS)

Open the HNSC breakdown →