KCNJ18

Across TCGA pan-cancer cohorts, KCNJ18 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of KCNJ18’s most consistent transcriptional readouts.

The strongest signal is observed in rectum adenocarcinoma (READ), where KCNJ18 RNA is repressed in tumor relative to normal tissue. In most cancer types KCNJ18 is over-expressed in tumor, although a few such as READ and PRAD show the opposite, repressed pattern.

READ, LUSC, and LUAD are the cancer types where KCNJ18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNJ18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
READ	All	III,IV	−0.235	.011	4	view →
LUSC	All	All	+0.249	.016	2	view →
LUAD	All	All	+0.176	.019	2	view →
PRAD	All	All	−0.046	.003	2	view →
THCA	All	II,III,IV	−0.013	.038	2	view →
HNSC	Male	III,IV	+0.606	.029	1	view →
KICH	All	III,IV	−0.025	.026	1	view →
KIRC	All	All	+0.013	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

KCNJ18–READ

Open the READ breakdown →