KCNJ16

Across TCGA patient cohorts, KCNJ16 mutation is significantly associated with the RNA expression of many other genes, with 5,593 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ16-associated genes across cancer lineages are MIR3135A, HELLS, and C22orf46. Each is linked with KCNJ16 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNJ16-to-partner and partner-to-KCNJ16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3135A grouped by KCNJ16-low versus KCNJ16-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ16→partner) and Y-score (partner→KCNJ16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR3135A →	+0.616	+2.998	<.001	.003	3	4
UCEC	HELLS →	+0.593	+2.279	<.001	<.001	3	3
SKCM	C22orf46 →	+0.685	+3.207	<.001	.009	3	3
SKCM	ATP6AP1L →	+0.562	+3.341	<.001	.005	3	3
SKCM	RNU6ATAC26P →	+0.245	+2.862	<.001	.005	3	3
UCEC	USP14 →	+0.487	+3.191	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,593 associations by consensus.

MIR3135A by KCNJ16 expression — LUSC

Explore this box plot interactively →