KCNJ16

Across TCGA pan-cancer cohorts, KCNJ16 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated KCNJ16 data layer compared with 10 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KCNJ16 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KCNJ16 expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

KIRC, KIRP, and OV are the cancer types where KCNJ16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.779	0.530	<.001	145	view →
KIRP	OS	Median	All	0.809	0.588	.001	52	view →
OV	DFS	Quartile	III,IV	0.592	0.487	.011	44	view →
UVM	OS	Quartile	III,IV	0.246	0.758	.011	42	view →
LAML	DFS	Median	All	0.329	0.610	<.001	42	view →
ACC	DFS	Tertile	All	0.823	0.167	.001	30	view →
BRCA	OS	Quartile	III,IV	0.663	0.418	.009	28	view →
SKCM	DFS	Median	All	0.673	0.576	.003	24	view →
THCA	DFS	Median	All	0.888	0.772	.002	24	view →
LIHC	OS	Quartile	All	0.429	0.650	<.001	22	view →
LUAD	DFS	Tertile	IV	0.240	0.949	.006	15	view →
PRAD	DFS	Median	All	0.878	0.644	.001	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

KCNJ16–KIRC (OS)

Open the KIRC breakdown →