KCNJ16

Across TCGA patient cohorts, KCNJ16 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ16-associated genes across cancer lineages are 4E-BP1, Cyclin-E2, and INPP4B. Each is linked with KCNJ16 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNJ16-to-partner and partner-to-KCNJ16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by KCNJ16-low versus KCNJ16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ16→partner) and Y-score (partner→KCNJ16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.323	+2.999	<.001	<.001	3	3
UCEC	Cyclin-E2 →	+0.131	+1.372	.012	.022	3	3
COAD	INPP4B →	-0.411	-3.169	.019	.018	3	2
COAD	TSC1 →	-0.467	-3.313	<.001	.010	3	2
COAD	Caspase-7-cleavedD198 →	+1.270	+3.330	<.001	.005	3	2
UCEC	Cyclin-B1 →	+0.716	+3.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

4E-BP1 by KCNJ16 expression — UCEC

Explore this box plot interactively →