KCNJ16

Across TCGA cell cohorts, KCNJ16 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible KCNJ16-associated genes across cancer lineages are SAA4, KRTAP5-6, and ETDB. Each is linked with KCNJ16 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ16-to-partner and partner-to-KCNJ16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAA4 grouped by KCNJ16-low versus KCNJ16-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ16→partner) and Y-score (partner→KCNJ16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SAA4 →	+0.154	+3.887	<.001	.005	3	1
LUNG_SCLC	KRTAP5-6 →	+0.119	+3.898	.008	.005	3	1
LUNG_SCLC	ETDB →	+0.092	+3.736	.003	.007	3	1
LUNG_SCLC	OR1D4 →	+0.028	+4.058	<.001	.007	3	1
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SAA4 by KCNJ16 expression — LUNG_SCLC

Explore this box plot interactively →