Across TCGA pan-cancer cohorts, KCNJ11 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KCNJ11 data layer compared with 27 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher KCNJ11 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KCNJ11 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

CESC, UCEC, and COAD are the cancer types where KCNJ11 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.068	0.830	<.001	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	OS	Median	All	0.485	0.802	.026	3	view →
BLCA	DFS	Median	IV	1.000	0.340	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: KCNJ11 tumor-vs-normal RNA expression · all KCNJ11 data types