Across TCGA patient cohorts, KCNJ11 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ11-associated genes across cancer lineages are JNK_pT183_Y185, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with KCNJ11 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ11-to-partner and partner-to-KCNJ11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ11→partner) and Y-score (partner→KCNJ11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.190	-1.893	.004	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.665	+2.019	.005	.017	3	2
UCEC	EGFR_pY1068 →	-0.247	-2.321	.014	.034	3	1
UCEC	ERK2 →	+0.152	+1.874	.049	.049	3	1
UCEC	FOXO3a_pS318_S321 →	-0.165	-2.115	<.001	.016	3	1
UCEC	HER3_pY1289 →	+0.104	+3.479	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

KCNJ11 survival (RNA) · tumor vs normal (RNA) · all KCNJ11 data types