KCNJ10

Across TCGA patient cohorts, KCNJ10 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ10-associated genes across cancer lineages are Caspase-7-cleavedD198, Ku80, and eIF4E. Each is linked with KCNJ10 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNJ10-to-partner and partner-to-KCNJ10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KCNJ10-low versus KCNJ10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ10→partner) and Y-score (partner→KCNJ10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.510	+3.341	.049	.005	3	3
SKCM	Ku80 →	+0.350	+3.000	.019	.035	3	2
UCEC	eIF4E →	+0.197	+2.115	.032	.019	3	2
UCEC	ASNS →	+0.394	+2.115	.012	.019	3	2
UCEC	EGFR_pY1068 →	-0.284	-2.807	.009	.003	3	1
UCEC	A-Raf_pS299 →	-0.205	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Caspase-7-cleavedD198 by KCNJ10 expression — UCEC

Explore this box plot interactively →