KCNJ10

Across TCGA pan-cancer cohorts, KCNJ10 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KCNJ10’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KCNJ10 RNA is repressed in tumor relative to normal tissue. In most cancer types KCNJ10 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where KCNJ10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNJ10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−5.343	<.001	12	view →
KIRP	Female	II,III,IV	−5.640	<.001	11	view →
KICH	Male	All	−5.630	<.001	11	view →
LUAD	All	All	+0.609	<.001	6	view →
BRCA	Female	All	+0.479	<.001	6	view →
HNSC	All	II,III,IV	+0.132	.007	6	view →
LIHC	Male	III,IV	−0.942	<.001	4	view →
STAD	All	II,III,IV	+0.724	.006	4	view →
BLCA	Male	All	+0.303	.015	4	view →
LUSC	Male	All	+0.437	.002	3	view →
UCEC	All	All	+0.306	.002	2	view →
COAD	All	All	−0.166	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KCNJ10–KIRC

Open the KIRC breakdown →