KCNJ10

Across TCGA cell cohorts, KCNJ10 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,099 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KCNJ10-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Regulation of mRNA splicing, via spliceosome. Each is linked with KCNJ10 in more than 9 cancer types. Because this analysis shows association rather than direction, both KCNJ10-to-partner and partner-to-KCNJ10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by KCNJ10-low versus KCNJ10-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ10→partner) and Y-score (partner→KCNJ10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.108	+0.279	<.001	<.001	3	10
OVARY	Negative regulation of myoblast fusion →	+0.108	+0.279	<.001	<.001	3	9
OVARY	Regulation of mRNA splicing, via spliceosome →	+0.066	+0.164	<.001	.001	3	9
OVARY	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.045	+0.117	<.001	.009	3	9
OVARY	mRNA splicing, via spliceosome →	+0.045	+0.117	<.001	.009	3	9
OVARY	Cytoplasmic translation →	+0.088	+0.219	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,099 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by KCNJ10 expression — OVARY

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