KCNJ10

Across TCGA cell cohorts, KCNJ10 mutation is significantly associated with the mutation status of many other genes, with 850 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNJ10-associated genes across cancer lineages are CD33, SIAE, and TPP1. Each is linked with KCNJ10 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNJ10-to-partner and partner-to-KCNJ10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD33 grouped by KCNJ10-low versus KCNJ10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ10→partner) and Y-score (partner→KCNJ10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CD33 →	+5.672	+5.672	<.001	<.001	1	3
LARGE_INTESTINE	SIAE →	+3.672	+4.799	.002	.002	1	3
LARGE_INTESTINE	TPP1 →	+3.087	+4.392	.005	.005	1	3
LARGE_INTESTINE	ZNF664 →	+5.087	+4.523	.006	.006	1	2
LARGE_INTESTINE	DCAF4L1 →	+2.865	+4.217	.007	.007	1	2
LARGE_INTESTINE	KBTBD3 →	+3.672	+4.799	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 850 associations by consensus.

CD33 by KCNJ10 expression — LARGE_INTESTINE

Explore this box plot interactively →