KCNJ1

Across TCGA cell cohorts, KCNJ1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible KCNJ1-associated genes across cancer lineages are IL36A, OR2D3, and SNTN. Each is linked with KCNJ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ1-to-partner and partner-to-KCNJ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36A grouped by KCNJ1-low versus KCNJ1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ1→partner) and Y-score (partner→KCNJ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IL36A →	+0.038	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR2D3 →	+0.028	+4.930	<.001	.008	3	1
SOFT_TISSUE	SNTN →	+0.023	+5.977	<.001	.001	3	1
SOFT_TISSUE	SPANXN4 →	+0.929	+4.930	<.001	.008	3	1
SOFT_TISSUE	POU3F4 →	+0.454	+4.930	<.001	.008	3	1
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IL36A by KCNJ1 expression — SOFT_TISSUE

Explore this box plot interactively →