KCNH6

Across TCGA patient cohorts, KCNH6 mutation is significantly associated with the RNA expression of many other genes, with 4,747 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNH6-associated genes across cancer lineages are TYMSOS, ZWINT, and MTFP1. Each is linked with KCNH6 in more than 4 cancer types. Because this analysis shows association rather than direction, both KCNH6-to-partner and partner-to-KCNH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMSOS grouped by KCNH6-low versus KCNH6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH6→partner) and Y-score (partner→KCNH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TYMSOS →	+0.739	+3.483	<.001	.002	3	5
UCEC	ZWINT →	+0.752	+1.830	<.001	<.001	3	4
STAD	MTFP1 →	+0.753	+3.203	<.001	.009	3	4
UCEC	FEN1 →	+0.634	+1.664	<.001	<.001	3	4
COAD	AURKB →	+0.654	+3.713	<.001	<.001	3	4
UCEC	H2AZ1 →	+0.623	+2.076	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,747 associations by consensus.

TYMSOS by KCNH6 expression — LUSC

Explore this box plot interactively →