KCNH4

Across TCGA patient cohorts, KCNH4 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNH4-associated genes across cancer lineages are eEF2, TIGAR, and Dvl3. Each is linked with KCNH4 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNH4-to-partner and partner-to-KCNH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by KCNH4-low versus KCNH4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH4→partner) and Y-score (partner→KCNH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.311	+2.807	.007	.002	3	3
UCEC	TIGAR →	+0.097	+1.486	.049	.007	3	3
UCEC	Dvl3 →	+0.153	+1.459	.010	.012	3	3
SKCM	eIF4E →	+0.178	+2.321	.014	.032	3	2
UCEC	PDCD4 →	-0.522	-2.000	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.320	-2.700	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eEF2 by KCNH4 expression — UCEC

Explore this box plot interactively →