KCNH4

Across TCGA cell cohorts, KCNH4 mutation is significantly associated with the RNA expression of many other genes, with 743 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNH4-associated genes across cancer lineages are OR2T7, TMEM174, and GPR63. Each is linked with KCNH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNH4-to-partner and partner-to-KCNH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T7 grouped by KCNH4-low versus KCNH4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH4→partner) and Y-score (partner→KCNH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR2T7 →	+0.004	+4.058	<.001	.007	3	2
BREAST	TMEM174 →	+0.014	+4.087	<.001	<.001	3	2
BLOOD_Leukemia	GPR63 →	+1.127	+3.285	<.001	.004	3	2
BLOOD_Leukemia	SEMA4F →	+0.814	+3.489	.002	.001	3	2
BLOOD_Leukemia	STOX1 →	+0.760	+3.215	.002	.005	3	2
BLOOD_Leukemia	RTKN2 →	+1.270	+3.321	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 743 associations by consensus.

OR2T7 by KCNH4 expression — LUNG_SCLC

Explore this box plot interactively →