KCNH3

Across TCGA pan-cancer cohorts, KCNH3 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KCNH3 data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher KCNH3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KCNH3 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

SKCM, SARC, and SCLC are the cancer types where KCNH3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.138	0.841	<.001	23	view →
SARC	DFS	Median	All	0.095	0.613	<.001	15	view →
SCLC	DFS	Median	All	0.183	0.637	.001	12	view →
LIHC	DFS	Median	All	0.038	0.553	<.001	12	view →
PCPG	DFS	Median	All	0.063	0.924	<.001	6	view →
COAD	OS	Median	II,III,IV	1.000	0.772	.028	3	view →
UCEC	OS	Median	All	1.000	0.866	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KCNH3–SKCM (OS)

Open the SKCM breakdown →