KCNH3

Across TCGA pan-cancer cohorts, KCNH3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KCNH3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KCNH3 RNA is repressed in tumor relative to normal tissue. In most cancer types KCNH3 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and HNSC are the cancer types where KCNH3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNH3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−1.461	<.001	12	view →
KICH	Female	III,IV	−2.163	<.001	11	view →
HNSC	Male	All	+0.606	<.001	7	view →
UCEC	All	All	+2.083	<.001	6	view →
BRCA	Female	All	−0.871	<.001	6	view →
LUAD	Female	All	−0.784	<.001	5	view →
BLCA	Female	All	−0.305	.031	3	view →
CHOL	All	All	+2.668	.001	2	view →
LUSC	All	III,IV	−0.885	.040	2	view →
KIRP	Male	All	−0.734	.016	2	view →
PRAD	All	All	−0.492	<.001	2	view →
THCA	Female	All	+0.456	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KCNH3–KIRC

Open the KIRC breakdown →