KCNH3

Across TCGA patient cohorts, KCNH3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,267 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible KCNH3-associated genes across cancer lineages are NCS1, WNK4, and SPECC1L. Each is linked with KCNH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNH3-to-partner and partner-to-KCNH3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KCNH3 versus NCS1 in BRCA, with a Pearson correlation of -0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH3→partner) and Y-score (partner→KCNH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NCS1 →	-1.410	-1.814	<.001	<.001	3	2
BRCA	WNK4 →	+3.302	+2.488	<.001	<.001	3	2
GBM	SPECC1L →	-0.580	-1.441	.002	.001	3	1
GBM	PPIL2 →	-0.636	-1.464	<.001	<.001	3	1
GBM	YPEL1 →	-0.818	-1.245	.006	.001	3	1
GBM	SNRPD3 →	-0.689	-0.885	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,267 associations by consensus.

KCNH3 vs NCS1 — BRCA

Explore this scatter interactively →