KCNH3

Across TCGA patient cohorts, KCNH3 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNH3-associated genes across cancer lineages are PKC-b-II_pS660, Shc_pY317, and ATM. Each is linked with KCNH3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNH3-to-partner and partner-to-KCNH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by KCNH3-low versus KCNH3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH3→partner) and Y-score (partner→KCNH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-b-II_pS660 →	-0.386	-1.991	.007	.031	3	3
UCEC	Shc_pY317 →	-0.213	-2.662	<.001	<.001	3	3
UCEC	ATM →	-0.804	-4.392	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.641	+1.765	.003	.014	3	3
UCEC	Cyclin-B1 →	+0.575	+3.321	.006	.009	3	3
COAD	PDK1_pS241 →	-0.202	-3.446	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

PKC-b-II_pS660 by KCNH3 expression — COAD

Explore this box plot interactively →