KCNH3

Across TCGA cell cohorts, KCNH3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,105 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KCNH3-associated GO terms across cancer lineages are Nucleic acid catabolic process, RNA catabolic process, and Heterochromatin organization. Each is linked with KCNH3 in more than 11 cancer types. Because this analysis shows association rather than direction, both KCNH3-to-partner and partner-to-KCNH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleic acid catabolic process grouped by KCNH3-low versus KCNH3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH3→partner) and Y-score (partner→KCNH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nucleic acid catabolic process →	+0.052	+1.460	.001	<.001	2	12
BONE	RNA catabolic process →	+0.083	+1.469	<.001	<.001	3	10
STOMACH	Heterochromatin organization →	+0.069	+1.206	.001	<.001	3	10
STOMACH	Heterochromatin formation →	+0.071	+1.395	.001	.001	3	10
OESOPHAGUS	Negative regulation of transcription by RNA polymerase III →	+0.193	+1.516	.003	.008	3	10
BONE	Negative regulation of gene expression, epigenetic →	+0.091	+1.442	.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,105 associations by consensus.

Nucleic acid catabolic process by KCNH3 expression — BONE

Explore this box plot interactively →