KCNH3

Across TCGA cell cohorts, KCNH3 mutation is significantly associated with the RNA expression of many other genes, with 325 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNH3-associated genes across cancer lineages are C10orf53, PRRG3, and VWC2L. Each is linked with KCNH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNH3-to-partner and partner-to-KCNH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf53 grouped by KCNH3-low versus KCNH3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH3→partner) and Y-score (partner→KCNH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C10orf53 →	+0.007	+2.462	.003	.004	3	2
BLOOD_Leukemia	PRRG3 →	+0.007	+3.922	<.001	.002	3	2
BLOOD_Leukemia	VWC2L →	+0.008	+3.339	.002	.006	3	2
BLOOD_Lymphoma	PROKR2 →	+0.057	+4.350	<.001	.005	3	2
OESOPHAGUS	GPR31 →	+0.016	+4.906	<.001	.006	3	1
OESOPHAGUS	SPHKAP →	+0.006	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 325 associations by consensus.

C10orf53 by KCNH3 expression — LARGE_INTESTINE

Explore this box plot interactively →