KCNH3

Across TCGA cell cohorts, KCNH3 mutation is significantly associated with the mutation status of many other genes, with 6,110 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNH3-associated genes across cancer lineages are FLNB, AGAP1, and SCN8A. Each is linked with KCNH3 in more than 6 cancer types. Because this analysis shows association rather than direction, both KCNH3-to-partner and partner-to-KCNH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FLNB grouped by KCNH3-low versus KCNH3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH3→partner) and Y-score (partner→KCNH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FLNB →	+2.275	+2.949	.001	.001	1	7
UPPER_AERODIGESTIVE_TRACT	AGAP1 →	+4.954	+4.392	.008	.008	1	6
BREAST	SCN8A →	+2.857	+4.142	.008	.008	1	6
BLOOD_Lymphoma	HECW2 →	+3.025	+3.754	.006	.006	1	6
BLOOD_Lymphoma	TTC3 →	+3.025	+3.754	.006	.006	1	6
BLOOD_Leukemia	MICAL3 →	+2.119	+2.544	.006	.006	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,110 associations by consensus.

FLNB by KCNH3 expression — BLOOD_Leukemia

Explore this box plot interactively →