KCNH1

Across TCGA patient cohorts, KCNH1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,110 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KCNH1-associated genes across cancer lineages are LOXL3, PNOC, and CNTROB. Each is linked with KCNH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNH1-to-partner and partner-to-KCNH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KCNH1 versus LOXL3 in LSCC, with a Pearson correlation of -0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH1→partner) and Y-score (partner→KCNH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LOXL3 →	-0.572	-1.328	.002	.003	3	2
GBM	PNOC →	+0.647	+0.579	.003	<.001	3	2
LSCC	CNTROB →	-0.556	-1.068	<.001	.002	3	2
LSCC	RGMB →	-0.454	-0.796	.002	.006	3	2
GBM	PRODH →	+0.876	+0.852	<.001	<.001	3	1
GBM	SEPTIN3 →	+0.860	+0.498	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,110 associations by consensus.

KCNH1 vs LOXL3 — LSCC

Explore this scatter interactively →