KCNE4

Across TCGA cell cohorts, KCNE4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNE4-associated genes across cancer lineages are SH3GL2, OR10W1, and ACSM6. Each is linked with KCNE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNE4-to-partner and partner-to-KCNE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by KCNE4-low versus KCNE4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNE4→partner) and Y-score (partner→KCNE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.653	+3.474	<.001	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.009	+3.240	<.001	.004	3	1
LARGE_INTESTINE	ACSM6 →	+0.021	+3.584	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.206	+3.425	.004	<.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.133	+2.892	<.001	.003	3	1
LARGE_INTESTINE	CHSY3 →	+0.359	+3.252	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SH3GL2 by KCNE4 expression — LARGE_INTESTINE

Explore this box plot interactively →