KCNE3

Across TCGA cell cohorts, KCNE3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,414 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KCNE3-associated GO terms across cancer lineages are Positive regulation of amyloid precursor protein catabolic process, Regulation of membrane repolarization during cardiac muscle cell action potential, and Cortical actin cytoskeleton organization. Each is linked with KCNE3 in more than 7 cancer types. Because this analysis shows association rather than direction, both KCNE3-to-partner and partner-to-KCNE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of amyloid precursor protein catabolic process grouped by KCNE3-low versus KCNE3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNE3→partner) and Y-score (partner→KCNE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of amyloid precursor protein catabolic process →	+0.124	+3.159	<.001	<.001	3	8
BLOOD_Leukemia	Regulation of membrane repolarization during cardiac muscle cell action potential →	-0.322	-1.942	<.001	<.001	3	7
STOMACH	Cortical actin cytoskeleton organization →	+0.128	+3.850	<.001	<.001	3	7
BONE	Cytotoxic T cell degranulation →	+0.230	+3.318	<.001	<.001	3	7
STOMACH	Cellular response to alcohol →	+0.089	+3.615	.001	<.001	3	6
STOMACH	Potassium ion export across plasma membrane →	+1.687	+5.402	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,414 associations by consensus.

Positive regulation of amyloid precursor protein catabolic process by KCNE3 expression — STOMACH

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