KCNE2

Across TCGA patient cohorts, KCNE2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNE2-associated genes across cancer lineages are Myosin-IIa, Rab25, and TFRC. Each is linked with KCNE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNE2-to-partner and partner-to-KCNE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa grouped by KCNE2-low versus KCNE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNE2→partner) and Y-score (partner→KCNE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa →	+0.264	+3.177	.009	.010	3	1
UCEC	Rab25 →	-0.363	-2.321	.029	.035	3	1
UCEC	TFRC →	+0.704	+2.321	.008	.035	3	1
UCEC	Di-Ras3 →	-0.162	-3.459	.030	.005	3	1
UCEC	Chk2_pT68 →	-0.204	-2.321	.029	.035	2	1
UCEC	4E-BP1 →	+0.269	+3.459	.048	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Myosin-IIa by KCNE2 expression — UCEC

Explore this box plot interactively →