KCNE2

Across TCGA pan-cancer cohorts, KCNE2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated KCNE2 data layer compared with 4 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher KCNE2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KCNE2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

BRCA, HNSC, and UCS are the cancer types where KCNE2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	All	0.473	0.688	<.001	97	view →
HNSC	DFS	Quartile	II,III,IV	0.793	0.599	.002	82	view →
UCS	DFS	Quartile	II,III,IV	0.603	0.113	.006	46	view →
SCLC	DFS	Quartile	All	0.507	0.807	.001	40	view →
LUSC	DFS	Quartile	II,III,IV	0.741	0.523	.004	35	view →
KIRC	DFS	Median	All	0.538	0.715	<.001	34	view →
UCEC	DFS	Tertile	All	0.509	0.822	<.001	32	view →
UVM	OS	Median	III,IV	0.318	1.000	.013	31	view →
LAML	DFS	Median	All	0.334	0.614	.018	28	view →
CHOL	DFS	Tertile	II,III,IV	0.127	0.754	.006	27	view →
SKCM	DFS	Median	All	0.243	0.157	.002	20	view →
THYM	OS	Median	II,III,IV	0.882	1.000	.007	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

KCNE2–BRCA (OS)

Open the BRCA breakdown →