KCNE1

Across TCGA patient cohorts, KCNE1 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNE1-associated genes across cancer lineages are MIR6859-2, SNORD115-4, and MIR638. Each is linked with KCNE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNE1-to-partner and partner-to-KCNE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6859-2 grouped by KCNE1-low versus KCNE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNE1→partner) and Y-score (partner→KCNE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6859-2 →	+0.493	+3.105	<.001	.005	3	1
LUAD	SNORD115-4 →	+0.238	+7.930	<.001	.008	3	1
BLCA	MIR638 →	+0.419	+7.640	<.001	.009	3	1
UCEC	MIR1273C →	+0.950	+3.279	<.001	.002	3	1
UCEC	KYNUP2 →	+0.051	+4.137	<.001	.008	3	1
UCEC	APOA5 →	+0.532	+3.738	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

MIR6859-2 by KCNE1 expression — UCEC

Explore this box plot interactively →