KCNC4

Across TCGA patient cohorts, KCNC4 mutation is significantly associated with the RNA expression of many other genes, with 3,284 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNC4-associated genes across cancer lineages are MED27, SENP3-EIF4A1, and CRELD2. Each is linked with KCNC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNC4-to-partner and partner-to-KCNC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED27 grouped by KCNC4-low versus KCNC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNC4→partner) and Y-score (partner→KCNC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MED27 →	+0.428	+4.172	<.001	<.001	3	3
UCEC	SENP3-EIF4A1 →	+0.099	+2.006	<.001	.007	3	3
UCEC	CRELD2 →	+0.473	+3.931	.001	<.001	3	3
UCEC	GAS2L1 →	+0.438	+1.914	<.001	.009	3	3
LUSC	VN1R6P →	+0.079	+4.853	<.001	.004	3	3
UCEC	ILKAP →	+0.261	+1.836	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,284 associations by consensus.

MED27 by KCNC4 expression — UCEC

Explore this box plot interactively →