KCNC3

Across TCGA cell cohorts, KCNC3 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KCNC3-associated genes across cancer lineages are OR52H1, ASB17, and C1QA. Each is linked with KCNC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNC3-to-partner and partner-to-KCNC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52H1 grouped by KCNC3-low versus KCNC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNC3→partner) and Y-score (partner→KCNC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR52H1 →	+0.033	+4.347	<.001	.001	3	1
STOMACH	ASB17 →	+0.026	+3.432	<.001	.008	3	1
LUNG_SCLC	C1QA →	+0.323	+4.070	<.001	.003	3	1
LUNG_SCLC	HTR3D →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF17 →	+0.008	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR52H1 by KCNC3 expression — LARGE_INTESTINE

Explore this box plot interactively →