KCNB2

Across TCGA patient cohorts, KCNB2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNB2-associated genes across cancer lineages are FoxM1, 4E-BP1, and Cyclin-B1. Each is linked with KCNB2 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNB2-to-partner and partner-to-KCNB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by KCNB2-low versus KCNB2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNB2→partner) and Y-score (partner→KCNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FoxM1 →	+0.256	+2.203	.006	.031	3	4
UCEC	4E-BP1 →	+0.264	+2.321	.004	.033	3	4
UCEC	Cyclin-B1 →	+0.488	+1.514	.010	.015	3	3
SKCM	MYH11 →	-0.554	-1.180	.004	.003	3	3
COAD	Caspase-7-cleavedD198 →	+1.307	+3.178	<.001	<.001	3	3
COAD	Smad4 →	+0.121	+2.008	.010	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

FoxM1 by KCNB2 expression — LUAD

Explore this box plot interactively →