KCNB2

Across TCGA pan-cancer cohorts, KCNB2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated KCNB2 data layer compared with 6 for mutation status.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher KCNB2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KCNB2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PAAD show a favorable association.

DLBC, UVM, and LUAD are the cancer types where KCNB2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	III,IV	0.226	0.903	<.001	66	view →
UVM	DFS	Tertile	All	0.327	0.860	<.001	51	view →
LUAD	OS	Tertile	II,III,IV	0.814	0.636	.001	41	view →
PAAD	DFS	Tertile	All	0.406	0.150	<.001	36	view →
OV	OS	Median	IV	0.240	0.506	<.001	36	view →
UCEC	DFS	Quartile	All	0.757	0.878	<.001	34	view →
LGG	DFS	Median	All	0.460	0.354	<.001	31	view →
THCA	DFS	Median	III,IV	0.733	0.948	.001	23	view →
THYM	DFS	Tertile	All	0.495	1.000	.001	22	view →
BLCA	OS	Quartile	All	0.505	0.638	.023	12	view →
COAD	DFS	Quartile	IV	0.243	0.513	.013	12	view →
KIRC	DFS	Tertile	II,III,IV	0.871	0.689	.029	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

KCNB2–DLBC (DFS)

Open the DLBC breakdown →