KCNB2

Across TCGA cell cohorts, KCNB2 mutation is significantly associated with the RNA expression of many other genes, with 719 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNB2-associated genes across cancer lineages are KRT1, GYS2, and HSCB. Each is linked with KCNB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNB2-to-partner and partner-to-KCNB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT1 grouped by KCNB2-low versus KCNB2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNB2→partner) and Y-score (partner→KCNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KRT1 →	+0.899	+3.874	<.001	.006	3	2
SKIN	GYS2 →	+0.008	+2.882	.001	.005	3	2
LARGE_INTESTINE	HSCB →	+0.575	+2.628	.001	.002	3	2
LARGE_INTESTINE	INTS10 →	+0.722	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	TGFBI →	-2.380	-3.169	.002	.006	3	2
LARGE_INTESTINE	ARL1 →	+0.448	+3.474	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 719 associations by consensus.

KRT1 by KCNB2 expression — CNS

Explore this box plot interactively →