KCNAB1-AS2

Across TCGA pan-cancer cohorts, KCNAB1-AS2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of KCNAB1-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KCNAB1-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KCNAB1-AS2 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where KCNAB1-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNAB1-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.202	<.001	11	view →
KIRC	All	All	−0.106	<.001	7	view →
KICH	All	All	−0.298	.002	6	view →
THCA	All	All	−0.101	<.001	6	view →
BRCA	Female	All	+0.145	<.001	4	view →
LUSC	Male	All	+0.110	<.001	4	view →
KIRP	All	IV	−0.642	.038	2	view →
UCEC	All	All	+0.087	.029	2	view →
LUAD	Female	All	+0.077	.006	2	view →
LIHC	All	II,III,IV	+0.030	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

KCNAB1-AS2–HNSC

Open the HNSC breakdown →